Infectious Disease Compendium

Zidovudine (Retrovir®)

Combivir is zidovudine + lamuvudine, take one po bid.

Dosing

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/tables.

CrCl > 80: 300 mg po q 12 h or 200 mg po q 8 h.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Anemia, neutropenia, anorexia, constipation, nausea, vomiting, asthenia, headache, insomnia, malaise, lactic acidosis/hepatomegaly with steatosis, myopathy.

Important drug interactions

Dapsone, doxorubicin, flucytosine, ganciclovir, interferon alfa, interferon beta, interferon beta-1a, methadone, nelfinavir, probenecid, pyrazinamide, pyrimethamine, ribavirin, rifabutin, rifampin, rifapentine, stavudine, valacyclovir, valproic acid, vinblastine, vincristine.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV.

Don't use for

Class

Nucleoside reverse transcriptase inhibitor.