Infectious Disease Compendium

Zalcitabine (Hivid®)

Dosing

CrCl Formula

CrCl > 80: 750 mg q 8 h.

CrCl 80-50:q 8 h

CrCl 50-10: q 12 h

CrCl < 10: q 24 h

Hemodialysis: ?

Peritoneal dialysis:?

Important side effects

Abnormal liver function tests, anemia, granulocytopenia, lactic acidosis/severe hepatomegaly with steatosis, oral ulcers, oral ulcers, pancreatitis, pancreatitis, peripheral neuropathy (common).

Important drug interactions

Aluminum carbonate, basic, aluminum hydroxide, aluminum phosphate, calcium, cimetidine, didanosine, dihydroxyaluminum aminoacetate, dihydroxyaluminum sodium carbonate, lamivudine, magaldrate, magnesium carbonate, magnesium hydroxide, magnesium oxide, magnesium trisilicate, pentamidine, probenecid, ribavirin.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV.

Don't use for

Class

Nucleoside reverse transcriptase inhibitor.