Infectious Disease Compendium

Valganciclovir (Valcyte®)

Dosing

CrCl Formula

CrCl > 80: 900 mg po bid for induction, 900 qd for prevention and maintenance.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Abdominal pain, diarrhea, nausea, vomiting, anemia, neutropenia (very common), thrombocytopenia, headache, insomnia.

Important drug interactions

Probenecid, zidovudine.

Rants and Screeds

I would avoid where absorbtion may be an issue, such as colitis.

Pearls

Treatment of choice

Use for

CMV retinitis. Perhaps other manifestations of CMV, it achieves blood levels nearly as good as iv.

Don't use for

Class