Infectious Disease Compendium

Trimetrexate (NeuTrexin®)

Dosing

CrCl Formula

CrCl > 80: 45 mg/m2 iv q d.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Nausea, vomiting, stomatitis, hepatotoxicity, myelosuppression, rash, renal toxicity.

Important drug interactions

Use with folinic acid 20 mg/m2 po or iv q 6. Cimetidine, clotrimazole, erythromycin, fluconazole, itraconazole, ketoconazole, miconazole, rifabutin, rifampin.

Rants and Screeds

Pearls

Treatment of choice

Use for

Pneumocystis cariini as a last ditch therapy.

Don't use for

Class