Infectious Disease Compendium

Trimethoprim

Dosing

CrCl Formula

CrCl > 80: 100 mg po q 12 h.

CrCl 80-50: 100 mg po q 12 h.

CrCl 50-10:100 mg po q 18-24 h.

CrCl < 10: avoid

Hemodialysis:

Peritoneal dialysis:

Important side effects

Blood dyscrasias, pruritus, rash, severe hypersensitivity reactions.

Important drug interactions

Anisindione, antipsychotics, arsenic trioxide, astemizole, bepridil, chloral hydrate, chloroquine, cisapride, clarithromycin, class i antiarrhythmic agents, class ia antiarrhythmic agents, class iii antiarrhythmic agents, cyclosporine, dapsone, digoxin, dofetilide, dolasetron, droperidol, enalapril maleate, enalaprilat, enflurane, erythromycin, fluconazole, fluoxetine, foscarnet, fosphenytoin, gemifloxacin, halofantrine, halothane, isoflurane, isradipine, levomethadyl, lidoflazine, mefloquine, mesoridazine, metformin, methotrexate, octreotide, pentamadine, phenothiazines, phenytoin, pimozide, probucol, pyrimethamine, quinapril, rosiglitazone, spiramycin, telithromycin, terfenadine, thioridazine, tolbutamide, tricyclic antidepressants, vasopressin, venlafaxine, ziprasidone, zolmitriptan.

Rants and Screeds

Pearls

Treatment of choice

Use for

UTI, Pneumocystis.

Don't use for

Class