Infectious Disease Compendium

Tipranavir (Aptivus®)

Dosing

CrCl Formula

For up-to-date information, go to

http://hivinsite.ucsf.edu/tables.

CrCl > 80: 500 mg BID + ritonavir 200 mg BID.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Diarrhea, nausea, vomiting, rash (more common in women). Liver toxicity, esp in patients with chronic hepatitis B or C.

Important drug interactions

Many. Don't use with rifampin amoung others.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV.

Class

Protease inhibitor.