Infectious Disease Compendium

Terbinafine (Lamisil®)

Dosing

CrCl Formula

CrCl > 80: 125 - 250 mg po q 12 - 24 h.

CrCl 80-50: 125 - 250 mg po q 12 - 24 h.

CrCl 50-10: ?

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

headache, liver failure, hepatitis, nausea, vomiting, severe neutropenia.

Important drug interactions

Cyclosporine, nortriptyline, rifampin, warfarin.

Rants and Screeds

I think the drug is worse than the disease.

Pearls

Treatment of choice

Use for

Dermatophytosis and superficial mycoses aka athlete's foot, chromoblastomycosis, cutaneous Leishmania, cutaneous Sporothrix, fungal joint infection, jock itch, Onychomycosis, otitis externa, paracoccidioidomycosis, pyoderma, Ringworm, seborrheic dermatitis, systemic mycoses, tinea capitis, tinea corporis, tinea cruris, tinea pedis, tinea unguium.

Don't use for

Class