Infectious Disease Compendium

Tedizolid (Sivexro®)

CID 2015 review

Dosing

CrCl Formula

CrCl > 80: 200 mg po or iv qd

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Obesity dosing

Important side effects

GI upset and headache.

Has the same hematologic effects as linezolid in short course (10 d) of therapy.  Tedizolid may have less gastrointestinal and hematologic side effects and does not have drug interactions with selective serotonin reuptake inhibitors compared to linezolid.

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

Approved for the treatment of cellulitis. 200 mg a day for 6 days (PubMed). Effective against most gram positives.

Don't use for

Class

Oxazolidinone. Static.