Infectious Disease Compendium

Suramin (Germanin®)

Dosing

CrCl Formula

CrCl > 80: 100 - 200 mg test dose then 1 gm IV.

Important side effects

Urticaria, papular eruptions, acute renal failure, elevated hepatic enzymes, fever and chills, headache, metallic taste, paresthesia, neuropathy, and fatigue, leukopenia, agranulocytosis, thrombocytopenia, coagulopathy, anemia, marrow depression, and increased prothrombin time, optic atrophy, pruritus, shock(common), elevated bilirubin, elevated transaminase levels, and elevated hepatic enzymes are described with the administration of suramin., rash, pruritus, urticaria, papular eruption.

Important drug interactions

Rants and Screeds

There is more to treating African sleeping sickness than looking up the dose in this guide.

Pearls

Treatment of choice

Use for

African sleeping sickness.

Don't use for

Class