Infectious Disease Compendium

Sulfadiazine

Dosing

CrCl Formula

CrCl > 80: (Toxoplasma treatment)

<60 kg: 1 g po q 6 hours plus pyrimethamine 50 mg po qd.

>=60 kg: Sulfadiazine 1500 mg po q 6 hours plus pyrimethamine 75 mg po qd.

Add leucovorin 10 to 20 mg/day orally (may increase up to 50 mg/day).

Important side effects

Allergic reactions, blood dyscrasias, crystalluria, renal failure (AIDS patients), diarrhea, nausea, severe hypersensitivity.

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

Toxoplasma, in combination, sulfadiazine and pyrimethamine.

Don't use for

Class

Sulfonamide.