Infectious Disease Compendium

Saquinavir (Fortovase®)

Dosing

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/tables.

CrCl > 80: 600 mg - 1.2 g po q 8 h. Saquinavir (soft gel capsule) 1200 mg po tid.

HIV infection: (with low-dose ritonavir) saquinavir (soft gel capsule) 1000 mg and ritonavir 100 mg po bid OR saquinavir (soft gel capsule) 400 mg and ritonavir 400 mg po bid.

Important side effects

Abdominal discomfort, diarrhea, dyspepsia, nausea, asthenia, diabetes mellitus, hyperglycemia, fat redistribution.

Important drug interactions

Alfentanil, alfuzosin, alprazolam, amiodarone, amlodipine, amprenavir, astemizole, atazanavir, atorvastatin, bepridil, bitter orange, carbamazepine, cerivastatin, cimetidine, cisapride, clarithromycin, cyclosporine, dapsone, delavirdine, dexamethasone, diltiazem, disopyramide, efavirenz, eletriptan, ergot derivatives, erlotinib, felodipine, fentanyl, flecainide, flunarizine, fosamprenavir, fosphenytoin, fusidic acid, gallopamil, indinavir, isradipine, itraconazole, ketoconazole, lacidipine, levomethadyl, lovastatin, midazolam, nelfinavir, nevirapine, nicardipine, nifedipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, phenobarbital, phenytoin, pimozide, propafenone, quinidine, quinine, rifabutin, rifampin, rifapentine, ritonavir, sildenafil, simvastatin, sirolimus, st john's wort, tacrolimus, tadalafil, terfenadine, triazolam, vardenafil, verapamil, voriconazole, warfarin.

Rants and Screeds

Pearls

Usually used to boost other HIV medications, see HIV for more information.

Treatment of choice

Use for

HIV.

Don't use for

Class

Protease inhibitor.