Infectious Disease Compendium

Ritonivir (Norvir®)

Dosing

CrCl Formula

CrCl > 80: 600 mg po q 12 h.

With lopinavir it's Kaletra®.

HIV infection: initial 300 mg po bid, increase by 100 mg po bid, every 2 to 3 days, up to usual maintenance dose of 600 mg po bid.

HIV infection: (low-dose ritonavir with saquinavir) saquinavir (hard or soft gel capsule) 1000 mg and ritonavir 100 mgpo bid, OR saquinavir (hard or soft gel capsule) 400 mg and ritonavir 400 mg po bid.

HIV infection: (low-dose ritonavir with fosamprenavir; treatment-naive) fosamprenavir 1400 mg and ritonavir 200 mg po qd OR fosamprenavir 700 mg and ritonavir 100 mg po bid.

HIV infection: (low-dose ritonavir with fosamprenavir; treatment-experienced) fosamprenavir 700 mg and ritonavir 100 mg po bid.

HIV infection: (low-dose ritonavir with indinavir) indinavir 800 mg and ritonavir 100-200 mg po bid.

Important side effects

Anorexia, diarrhea, nausea, vomiting, asthenia (common), circumoral and peripheral paresthesias, taste perversion, diabetes mellitus/hyperglycemia, fat redistribution, hepatitis, increased bleeding in hemophilia patients, increased liver function tests, lipid disorders, lipid disorders, pancreatitis, pancreatitis.

Important drug interactions

Acenocoumarol, alfuzosin, alprazolam, amiodarone, amitriptyline, amprenavir, aprepitant, astemizole, atazanavir, atorvastatin, bepridil, bupropion, carbamazepine, cerivastatin, cisapride, clarithromycin, clonazepam, clorazepate, clozapine, cyclosporine, darifenacin, desipramine, dexamethasone, diazepam, didanosine, digoxin, diltiazem, disopyramide, dronabinol, dutasteride, efavirenz, eletriptan, encainide, ergot derivatives, erlotinib, estazolam, eszopiclone, ethinyl estradiol, ethosuximide, fentanyl, flecainide, fluoxetine, flurazepam, fluticasone, fusidic acid, imipramine, indinavir, itraconazole, ketoconazole, lamotrigine, levonorgestrel, levothyroxine, lidocaine, lovastatin, meperidine, mestranol, methadone, methylenedioxymethamphetamine, metoprolol, mexiletine, midazolam, nefazodone, nifedipine, norelgestromin, norethindrone, norgestrel, olanzapine, perphenazine, phenytoin, pimozide, prednisone, propafenone, propoxyphene, quinidine, quinine, quinupristin/dalfopristin, rifabutin, rifampin, rifapentine, risperidone, saquinavir, sildenafil, simvastatin, st john's wort, tacrolimus, tadalafil, tenofovir, terfenadine, theophylline, thioridazine, timolol, tipranavir, tramadol, trazodone, triazolam, vardenafil, verapamil, voriconazole, warfarin, zolpidem.

Rants and Screeds

Pearls

Treatment of choice

Use for:

HIV.

Don't use for

Use for

Protease inhibitor.