Infectious Disease Compendium

Rimantadine (Flumadine®)

Dosing

CrCl Formula

CrCl > 80: 100 mg po bid.

Important side effects

Anorexia, dry mouth, nausea, vomiting, dizziness, insomnia, nervousness, increased seizure activity in patients with seizures.

Important drug interactions

Rants and Screeds

Pearls

Less neurotoxic in the elderly than amantadine.

Treatment of choice

Use for

Influenza A (92% of influenza A is now resistant to amantadine and rimantadine; use zanamivir or olsatamivir).

Don't use for

Not influenza B. That's NOT B. B BBBBBBBBBB.

Class

M2 pump inhibitor that prevents viral uncoating.