Infectious Disease Compendium

Rifabutin (Mycobutin®)

Dosing

CrCl Formula

CrCl > 80: 300 mg po q 24 h.

Important side effects

Anorexia, diarrhea, dyspepsia, anemia, neutropenia, thrombocytopenia (rare), body-fluid and skin discoloration, ocular discoloration, mild transaminase elevation, nausea, vomiting, rash (common), systemic lupus erythematosus (rare), taste disorders, uveitis.

Important drug interactions

Amprenavir, atazanavir, atovaquone, azithromycin, clarithromycin, cyclosporine, dapsone, delavirdine, efavirenz, erlotinib, ethinyl estradiol, fluconazole, fosamprenavir, imatinib, indinavir, irinotecan, itraconazole, levonorgestrel, mestranol, nelfinavir, nevirapine, norelgestromin, norethindrone, ritonavir, saquinavir, sirolimus, tacrolimus, trimetrexate, voriconazole, warfarin, zidovudine.

Rants and Screeds

Pearls

Treatment of choice

Use for

MAI, Cryptosporidium, Helicobacter pylori, Toxoplasma, Tuberculosis.

Don't use for

Class