Infectious Disease Compendium

Raltegravir (Isentress®)

Dosing

CrCl Formula

CrCl > 80: 400 mg bid. If patients on rifampin the dose is 800 bid.

Important side effects

Low WBC, increase in transaminases and CK. Rash.

There is an association with HLA-B*53:01 and Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome (PubMed) Or should it be called DRESSS?

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Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV (PubMed).

Don't use for

Class

Integrase inhibitor. Popular with Strom Thurman and George Wallace.