Infectious Disease Compendium

Raltegravir (Isentress®)


CrCl Formula

CrCl > 80: 400 mg bid. If patients on rifampin the dose is 800 bid.

Important side effects

Low WBC, increase in transaminases and CK. Rash.

There is an association with HLA-B*53:01 and Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome (PubMed) Or should it be called DRESSS?


Important drug interactions

Rants and Screeds


Treatment of choice

Use for

HIV (PubMed).

Don't use for


Integrase inhibitor. Popular with Strom Thurman and George Wallace.