Infectious Disease Compendium

Pyrimethamine (Daraprim®)

Dosing

CrCl Formula

CrCl > 80: depends on what your treating.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Leukopenia, megaloblastic anemia, rash, Steven's-Johnson syndrome (rare).

Important drug interactions

Aurothioglucose, folic acid, lorazepam, methotrexate, sulfamethoxazole, trimethoprim, zidovudine.

Rants and Screeds

Pearls

Treatment of choice

Use for

Prophylaxis of toxoplasma and malaria.

Don't use for

Class