Infectious Disease Compendium

Pyrazinamide

Dosing

CrCl Formula

CrCl > 80: 15 - 30 mg/kg po q 24 h.

CrCl 80-50: 15 - 30 mg/kg po q 24 h.

CrCl 50-10: 15 - 30 mg/kg po q 24 h.

CrCl < 10: 12-20 mg/kg po q 24 h.

Hemodialysis: 12 to 20 mg/kg/day OR 40 mg/kg three times weekly OR 60 mg/kg twice weekly.

Peritoneal dialysis:

Important side effects

Arthralgia (common), anemia, hepatotoxicity, hyperuricemia, nausea, vomiting.

Important drug interactions

Cyclosporine, ethionamide, probenecid, rifampin, zidovudine.

Rants and Screeds

Pearls

Treatment of choice

Use for

Mtb

Don't use for

Class