Infectious Disease Compendium

Posaconazole (Noxafil®)

Dosing

CrCl Formula

CrCl > 80: 200 mg tid. Only comes po.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

These drugs interact with damn near everything else so check with you pharmacist or this reference at CID.

Rants and Screeds

Pearls

Low serum levels are associated with breakthrough fungal infections (PubMed). And high levels are associated with toxicity (PubMed). So iff you can, get a level in patients on the drug long term .

Treatment of choice

Zygomycetes.

Use for

Aspergillus fumigatus - disseminated, Candida, Cryptococcus neoformans, Fusarium, disseminated phaeohyphomycosis, disseminated zygomyces. Fungal prophylaxis in graft vrs host disease.

Don't use for

Class

Triazole.