CrCl > 80: 200 to 300 mg per kg per day in 2 - 4 divided doses.
CrCl < 10:
Important side effects:
Abdominal pain, diarrhea, hepatotoxicity (common), hypersensitivity reactions, nausea, vomiting, thrombocytopenia.
Important drug interactions
Rants and Screeds
Treatment of choice
Second line for really resistant MTb.
Don't use for
Competitive antagonist of folic acid synthesis.