Infectious Disease Compendium

Para-aminosalicyclic acid

Dosing

CrCl Formula

CrCl > 80: 200 to 300 mg per kg per day in 2 - 4 divided doses.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects:

Abdominal pain, diarrhea, hepatotoxicity (common), hypersensitivity reactions, nausea, vomiting, thrombocytopenia.

Important drug interactions

Cyanocobalamin, digoxin, ethionamide, isoniazid.

Rants and Screeds

Pearls

Treatment of choice

Use for:

Second line for really resistant MTb.

Don't use for

Class

Competitive antagonist of folic acid synthesis.