Infectious Disease Compendium


CrCl Formula

CrCl > 80: 1 -2 gm iv q 4 h.

CrCl 80-50: 1 -2 gm iv q 4 h.

CrCl 50-10: 1 -2 gm iv q 4 h.

CrCl < 10: 1 -2 gm iv q 4 h.

Hemodialysis: 1 -2 gm iv q 4 h.

Peritoneal dialysis:

Important side effects

Allergic hepatitis, nephritis and marrow suppression.

Important drug interactions

Ethinyl estradiol, mestranol, norelgestromin, norethindrone, norgestrel.

Rants and Screeds


It is hard on peripheral veins which is why I use cefazolin for uncomplicated cellulitis.

Treatment of choice

S. aureus. Interchangeable with nafcillin. Arthritis, Cellulitis, Osteomyelitis, Pneumonia, surgical prophylaxis.

Use for


Don't use for Enterococci.