Infectious Disease Compendium

Oxacillin

CrCl Formula

CrCl > 80: 1 -2 gm iv q 4 h.

CrCl 80-50: 1 -2 gm iv q 4 h.

CrCl 50-10: 1 -2 gm iv q 4 h.

CrCl < 10: 1 -2 gm iv q 4 h.

Hemodialysis: 1 -2 gm iv q 4 h.

Peritoneal dialysis:

Important side effects

Allergic hepatitis, nephritis and marrow suppression.

Important drug interactions

Ethinyl estradiol, mestranol, norelgestromin, norethindrone, norgestrel.

Rants and Screeds

Pearls

It is hard on peripheral veins which is why I use cefazolin for uncomplicated cellulitis.

Treatment of choice

S. aureus. Interchangeable with nafcillin. Arthritis, Cellulitis, Osteomyelitis, Pneumonia, surgical prophylaxis.

Use for

Streptococci.

Don't use for Enterococci.

Class

Penicillin.