CrCl > 80: 1200 mg over 3 hours. With a half life of 400 hours, one dose is all that is needed for cellulitis.
CrCl < 10:
Important side effects
Elevated LFT's. Less side effects than vancomycin.
Important drug interactions
Rants and ScreedsIt costs. $917.56/400 mg vial x 3 vials = $2,752.69. Really. A fully loaded MacBook pro. There seems to be a new era of price gouging.
Treatment of choice
All gram postive including VRE and MRSA. Same spectrum as vancomycin, but much better MIC's. Only approved for cellulitis, for which it is no worse than vancomycin, the definition of damning with faint praise I suppose.
Don't use for
Relevant links to my Medscape blog