Infectious Disease Compendium

Novobiocin

Dosing

CrCl Formula

CrCl > 80: 250 mg q 6 hours or 5000 mg q 12 hours.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Agranulocytosis, diarrhea, eosinophilia, hemolytic anemia, leukopenia, nausea, pancytopenia, rash, thrombocytopenia, vomiting, yellow discoloration of skin, yellowing of the sclerae.

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

Staphylococcus aureus infections, UTI.

Don't use for