Infectious Disease Compendium

Nitazoxanide (Alinia®)

Dosing

CrCl Formula

CrCl > 80: Patients 12 years of age or older with diarrhea due to Giardia lamblia500 mgpo q 12 hours with food for 3 days. Clostridium difficile: 250 mg 4 times per day for 10 days or 500 mg 2 times per day for 10 days is as effective as metronidazole.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

The ususal hodgepodge of gi complaints.

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

Cryptosporidium and Giardia lamblia. Also Clostridium difficile in adults.

600 mg twice daily for 5 days was associated with a decrease in duration of symptoms in patients with acute uncomplicated influenza by about a day (PubMed).

Don't use for

Class