Infectious Disease Compendium

Nifurtimox

Dosing

CrCl Formula

CrCl > 80: 8 - 10 mg/kg/d in 3 - 4 doses.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

GI upset, all manner of CNS ( cns excitation, depression, fatigue, headache, memory impairment, paresthesias or peripheral neuropathy, tremors, vertigo or ataxia, weakness, sleep disorders).

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

Leishmania, Trypanosoma.

Don't use for

Class