Infectious Disease Compendium

Netilmicin

Dosing

CrCl Formula

CrCl > 80: 2 mg/kg iv q 8 h.

CrCl 80-50: 2 mg/kg iv q 8-12 h.

CrCl 50-10: 2 mg/kg iv q 12-48 h.

CrCl < 10: 2 mg/kg iv q >48 h.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Diarrhea, nausea, vomiting, nephrotoxicity, neuromuscular blockade, respiratory paralysis (concomitant anesthesia, muscle relaxants), ototoxicity.

Important drug interactions

Bumetanide, capreomycin, carboplatin, cidofovir, cyclosporine, ethacrynic acid, furosemide, lysine, magnesium, nondepolarizing neuromuscular blockers, penicillins, piretanide, succinylcholine, tacrolimus.

Rants and Screeds

Pearls

Treatment of choice

Use for

Gram-negative infections. Appendicitis, Cellulitis, Meningitis, Cystic fibrosis, Endocarditis treatment, Neutropenic fever, Gonorrhea, Intra abdominal infections, Peritonitis, Pneumonia, Sepsis, UTI.

Don't use for

Class

Aminoglycoside.