Infectious Disease Compendium

Neomycin

Dosing

CrCl Formula

CrCl > 80:

Hepatic coma: 2-4 g/day po every 4-6 hr for 5-6 days, maximum 12 g/day; do not use longer than 2 weeks.

Pre-operative bowel preparation: 1 g po q hour for 4 hours, then 1 g every 4 hr for the remaining 24 hr, or 1 g po 19, 18, and 9 hrs prior to surgery with oral erythromycin.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Diarrhea, nausea, vomiting, nephrotoxicity, neuromuscular blockade, respiratory paralysis (concomitant anesthesia, muscle relaxants), ototoxicity.

Important drug interactions

Anisindione, bumetanide, cidofovir, cyclosporine, dicumarol, digoxin, furosemide, methotrexate, nondepolarizing neuromuscular blockers, phenprocoumon, tacrolimus, warfarin.

Rants and Screeds

Pearls

Treatment of choice

Use for

Pre operative bowel decontamination, hepatic encephalopathy.

Don't use for

Class

Aminoglycoside.