Infectious Disease Compendium

Nelfinavir (Viracept®)

Dosing

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/tables.

CrCl > 80: 1250 mg po q 12 or 750 mg po q 8 h.

CrCl 80-50: 1250 mg po q 12 or 750 mg po q 8 h.

CrCl 50-10: 1250 mg po q 12 or 750 mg po q 8 h.

CrCl < 10: 1250 mg po q 12 or 750 mg po q 8 h.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Diabetes mellitus (new onset and exacerbation), hyperglycemia, diarrhea, fat redistribution.

Important drug interactions

Alfuzosin, amiodarone, amprenavir, aprepitant, astemizole, atorvastatin, azithromycin, cannabis, carbamazepine, caspofungin, cerivastatin, cisapride, cyclosporine, darifenacin, delavirdine, didanosine, eletriptan, ergot derivatives, erlotinib, eszopiclone, ethinyl estradiol, etonogestrel, felodipine, fentanyl, fosamprenavir, fosphenytoin, indinavir, lovastatin, mestranol, methadone, midazolam, norethindrone, norgestrel, phenobarbital, phenytoin, pimozide, quinidine, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, sildenafil, simvastatin, st john's wort, tacrolimus, tadalafil, terfenadine, triazolam, vardenafil, voriconazole, zidovudine.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV.

Don't use for

Class

Protease inhibitor.