Infectious Disease Compendium

Nalidixic Acid (NegGram®)

Dosing

CrCl Formula

CrCl > 80: 1 gm po q 6.

CrCl 80-50: 1 gm po q 6.

CrCl 50-10: 1 gm po q 6.

CrCl < 10: do not use.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Coma, diarrhea, dizziness, drowsiness, headache, hemolytic anemia, metabolic acidosis, n/v, peripheral neuropathy, photosensitivity, psychotic reactions, qt interval prolongation, rash, seizures, tendon rupture.

Important drug interactions

Antacids, cyclosporine, didanosine, disopyramide, melphalan, pirmenol, prajmaline, procainamide, quinidine, sucralfate, warfarin.

Rants and Screeds

Pearls

Treatment of choice

Use for

Cystitis.

Don't use for

Class

Affects bacterial DNA topoisomerase, the precursor of the quinolones we all know and love.