Infectious Disease Compendium

Nafcillin (Unipen®)


CrCl Formula

CrCl > 80: 1 - 2 g iv q 4 h.

CrCl 80-50: 1 - 2 g iv q 4 h.

CrCl 50-10: 1 - 2 g iv q 4 h.

CrCl < 10: 1 - 2 g iv q 4 h.

Hemodialysis: 1 - 2 g iv q 4 h.

Peritoneal dialysis:

Obesity dosing

Important side effects

Interstitial nephritis and bone marrow suppression.

Important drug interactions

Cyclosporine, nifedipine, warfarin.

Rants and Screeds


It is hard on peripheral veins which is why I use cefazolin for uncomplicated cellulitis. Interchangeable with oxacillin.

Treatment of choice

S. aureus. Arthritis, Brodies abscess, Cellulitis, Endocarditis, Impetigo, Meningitis, Osteomyelitis, Pneumonia, surgical prophylaxis.

Use for

All gram positive cocci except the enterococcus.

Don't use for