Infectious Disease Compendium

Mezlocillin (Mezlin®)

Dosing

CrCl Formula

CrCl > 80: 3 - 4 g iv q 6 h.

CrCl 80-50:

CrCl 30-10: 2 - 3 g iv q 8 h.

CrCl < 10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Usual.

Important drug interactions

Methotrexate.

Rants and Screeds

Pearls

Treatment of choice

Use for

An anti pseudomonal penicillin, it has been supplanted by piperacillin. Bacteremia, Bacteroides, Bites, animal and human, Cellulitis, cesarean section, Empyema, Endometritis, Escherichia coli, Gonorrhea, gynecological infections, Haemophilus, hysterectomy, Klebsiella, Lung abscess, Meningitis, Neutropenic fever, pelvic cellulitis, PID, pneumonia, Proteus, Pseudomonas, Sepsis, surgical prophylaxis, UTI.

Don't use for

Class

Penicillin.