Infectious Disease Compendium

Melarsopol

Dosing

CrCl Formula

CrCl > 80: 2-3.6 mg/kg/d IV x 3 d; after 1 wk 3.6 mg/kg/d IV x3d; repeat after 10-21 d.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Fever, abdominal pain, vomiting, and arthralgia. Reactive encephalopathy causes death in 6%.

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

Trypanosoma brucei.

Don't use for

Class