Infectious Disease Compendium

Mefloquin (Lariam®)

Dosing

CrCl Formula

CrCl > 80: 250 mg once a week for prevention; 1250 mg x 1 for treatment.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Psychosis and really weird and disturbing dreams. Like a Bush as president. Actually reality is worse than a dream. Also diarrhea, dizziness, drowsiness, extrasystoles, nausea, psychiatric symptoms, seizures (rare), sinus bradycardia, vomiting (3%).

Important drug interactions

Antipsychotics, arsenic trioxide, astemizole, aurothioglucose, bepridil, carbamazepine, chloral hydrate, chloroquine, cisapride, clarithromycin, class i antiarrhythmic agents, class ia antiarrhythmic agents, class iii antiarrhythmic agents, cotrimoxazole, dolasetron, droperidol, enflurane, erythromycin, erythromycin/sulfisoxazole, fluconazole, fluoxetine, foscarnet, gemifloxacin, halofantrine, halothane, isoflurane, isradipine, levomethadyl, lidoflazine, lumefantrine, mesoridazine, octreotide, pentamadine, phenobarbital, phenothiazines, phenytoin, pimozide, probucol, propranolol, quinidine, quinine, rifampin, spiramycin, sulfamethoxazole, telithromycin, terfenadine, thioridazine, trimethoprim, typhoid vaccine, live, valproic acid, vasopressin, venlafaxine, ziprasidone, zolmitriptan.

Rants and Screeds

Pearls

Treatment of choice

Use for

Malaria treatment and prophylaxis. Still have to treat liver phase with primaquine for P. vivax and P. ovale.

Don't use for

Class