Infectious Disease Compendium

Maraviroc

(PubMed)

Dosing

CrCl Formula

CrCl > 80:

No net alteration in metabolism: Tipranavir plus ritonavir, nevirapine, all NRTIs, and enfuvirtide 300 mg BID.

CYP3A inhibitors (with or without a CYP3A inducer): Ritonavir, all boosted protease inhibitors (except tipranavir plus ritonavir), delavirdine, ketoconazole, itraconazole, clarithromycin, nefazadone, and telithromycin 150 mg BID.

CYP3A inducers alone Efavirenz, etravirine, rifampin, carbamazepine, phenobarbital, and phenytoin 600 mg BID.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Hepatitis.

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV (Human immuodefiency virus)

Don't use for

Class

Inhibits the interaction between the chemokine receptor CCR5 and HIV-1 gp120.