Infectious Disease Compendium

Lamivudine (Epivir®)

Found in TrizivirR and CombivirR

Dosing

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/tables.

CrCl > 80: 150 mg po bid.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Anemia, neutropenia, diarrhea, nausea, vomiting, fatigue, headache, musculoskeletal pain, neuropathy, lactic acidosis/severe hepatomegaly with steatosis, myopathy, myositis.

Important drug interactions

Acetaminophen, dapsone, doxorubicin, flucytosine, ganciclovir, interferon alfa, interferon beta, interferon beta-1a, methadone, nelfinavir, probenecid, pyrazinamide, pyrimethamine, ribavirin, rifabutin, rifampin, rifapentine, stavudine, valgancyclovir, valproic acid, vinblastine, vincristine, zalcitabine.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV and Hepatitis B.

Don't use for

Class

Reverse transcriptase inhibitor.