Infectious Disease Compendium

Kanamycin

Dosing

CrCl Formula

CrCl > 80: 7.5 mg/kg q 12 hours or 15 mg/kg/day.

CrCl 80-50: 60% to 90% q 12 hours.

CrCl 50-10: 30% to 70% q 12 hours.

CrCl < 10: 20% to 30% q 24 to 48 hours.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Oto and nephrotoxicity.

Important drug interactions

Bumetanide, capreomycin, carboplatin, cephalosporins, cidofovir, cyclosporine, ethacrynic acid, furosemide, live typhoid vaccine, lysine, magnesium, nondepolarizing neuromuscular blockers, penicillins, piretanide, succinylcholine, tacrolimus.

Rants and Screeds

Pearls

Treatment of choice

Use for

Bowel sterilization, Endocarditis, Gonorrhea, gram-negative infections, hepatic encephalopathy, necrotizing enterocolitis, surgical infections, Tuberculosis, UTI.

Don't use for

Class

Aminoglycoside.