Infectious Disease Compendium

Kaletrea® (Lopinavir + Ritonivir)

Dosing

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/tables.

CrCl > 80: 3 po bid.

Concomitant nevirapine or efavirenz: 533/133 mg (4 capsules or 6.5mL) po bid.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Asthenia, headache, diabetes mellitus (new onset or exacerbation), hyperglycemia, diarrhea, nausea, elevations in total cholesterol and triglycerides, fat redistribution (less common), hepatotoxicity, pancreatitis.

Important drug interactions

Acenocoumarol, alfuzosin, alprazolam, amiodarone, amprenavir, aprepitant, astemizole, atazanavir, atorvastatin, bepridil, bupropion, cannabis, carbamazepine, cerivastatin, cisapride, clarithromycin, clonazepam, clorazepate, clozapine, cyclosporine, dalfopristin, darifenacin, desipramine, dexamethasone, diazepam, didanosine, digoxin, diltiazem, disopyramide, dronabinol, dutasteride, eletriptan, encainide, ergot derivatives, erlotinib, estazolam, eszopiclone, ethinyl estradiol, ethosuximide, fentanyl, flecainide, fluoxetine, flurazepam, fluticasone, fusidic acid, garlic, imipramine, indinavir, itraconazole, ketoconazole, lamotrigine, levonorgestrel, levothyroxine, lidocaine, lovastatin, meperidine, mestranol, methadone, methylenedioxymethamphetamine, metoprolol, mexiletine, midazolam, nefazodone, nelfinavir, nifedipine, norelgestromin, norethindrone, norgestrel, olanzapine, phenytoin, pimozide, prednisone, propafenone, propoxyphene, quinidine, quinine, quinupristin/dalfopristin, rifabutin, rifampin, rifapentine, risperidone, saquinavir, sildenafil, simvastatin, st john's wort, tacrolimus, tadalafil, tenofovir, terfenadine, theophylline, thioridazine, timolol, tipranavir, tramadol, trazodone, triazolam, vardenafil, verapamil, voriconazole, warfarin, zidovudine, zolpidem.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV

Don't use for

Class

Protease inhibitor.