Infectious Disease Compendium

Isoniazid

Dosing

CrCl Formula

CrCl > 80: 300 mg po qd.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Peripheral neuropathy, take with vitamin B6 to prevent. Age related chemical hepatitis, esp when age > 35. Agranulocytosis (rare), anemia (rare), seizures, skin reactions, systemic lupus erythematosus (rare), urticaria.

Important drug interactions

Acetaminophen, alprazolam, para-aminosalicyclic acid, carbamazepine, cycloserine, diazepam, disulfiram, enflurane, ethionamide, fosphenytoin, itraconazole, ketoconazole, levodopa, meperidine, phenytoin, rifampin, sevoflurane, valproic acid, warfarin.

Rants and Screeds

Pearls

Treatment of choice

Use for

Mycobacterium infections and prophylaxis.

Don't use for

Class