Infectious Disease Compendium

Isavuconazole (Cresemba®)

2015 Review. The brand name sounds like a Lion King Character.

Dosing

CrCl Formula

CrCl > 80: loading dose of 600 mg, given as 200 mg every 8 hours, for 2 days followed by 200 mg daily.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

Rifampin will decrease drug levels.

Rants and Screeds

Pearls

Treatment of choice

Use for

Cryptococcus, Paracoccidioides, Coccidioides, Histoplasma) and Blastomyces (Pubmed) have been successfully treated.

.

Aspergillus and Mucormycosis have most experience as of 2015; it has good MIC against a wide range of fungi but few clinical trials, see the above review.

Don't use for

Class

azole.