Infectious Disease Compendium

Indinavir (Crixivan®)

Dosing

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/tables.

CrCl > 80: 800 mg po tid.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Pure indinavir renal stones; the worlds most expensive stones. abdominal pain, nausea, vomiting, acute hemolytic anemia, asymptomatic hyperbilirubinemia, back pain, fat redistribution, hepatitis (including liver failure and death (rare)), hyperglycemia (including cases of new onset diabetes mellitus), immune reconstitution syndrome.

Important drug interactions

Alfuzosin, amiodarone, amprenavir, ascorbic acid, astemizole, amprenavir, atorvastatin, calcium channel blockers, carbamazepine, cerivastatin, cisapride, cyclosporine, dalfopristin, delavirdine, dexamethasone, didanosine, efavirenz, eletriptan, ergot derivatives, erlotinib, fentanyl, fosamprenavir, fosphenytoin, ivermectin, ketoconazole, levodopa, lovastatin, midazolam, nevirapine, phenobarbital, phenytoin, pimozide, quinupristin, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, sildenafil, simvastatin, st john's wort, tadalafil, terfenadine, trazodone hydrochloride, triazolam, vardenafil.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV.

Don't use for

Class

Protease inhibitor.