Infectious Disease Compendium

Imipenem (Primaxin®)

Dosing

CrCl Formula

CrCl > 80: 500 mg - 1 g iv q 6 h.

CrCl 80-50: 500 mg iv q 6 - 8 h.

CrCl 50-10: 500 mg q 8 - 12 h.

CrCl < 10: 250 - 500 mg iv q 12 h.

Hemodialysis: 250 - 500 mg after then q 12.

Peritoneal dialysis:

Important side effects

1) seizures if not dosed for CrCl.

2) 30% chance of cross reaction if a type 1 reaction to penicillin. Did you see that? 30%!. Holy spit. (Surprise, I actually censored myself).

Important drug interactions

Cyclosporine, ganciclovir, theophylline.

Rants and Screeds

Pearls

Treatment of choice

Use for

Damn near anything. Anthrax, Arthritis, Cellulitis, Cystic fibrosis, Diverticulosis/itis, Endocarditis, gynecologic infections, Intra abdominal infections, Meningitis, Neutropenic fever, Osteomyelitis, Peritonitis, Pneumonia, Sepsis, UTI.

Don't use for

Class

Carbapenem