Infectious Disease Compendium

Halofantrine (Halfan®)

Dosing

CrCl Formula

CrCl > 80: 500 mg po q 6 x 3d; may need to be repeated in a week.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Long qt and ventricular arrhythmias.

Important drug interactions

Antipsychotics, arsenic trioxide, astemizole, aurothioglucose, bepridil, chloral hydrate, chloroquine, chlorpromazine, cisapride, clarithromyci, class i antiarrhythmic agents, class ia antiarrhythmic agents, class iii antiarrhythmic agents, cotrimoxazole, dolasetron, droperidol, enflurane, erythromycin, erythromycin/sulfisoxazole, fluconazole, fluoxetine, foscarnet, gemifloxacin, halothane, isoflurane, isradipine, itraconazole, levomethadyl, lidoflazine, mefloquin, mesoridazine, octreotide, pentamadine, pimozide, probucol, prochlorperazine, spiramycin, sulfamethoxazole, telithromycin, telithromycin, thioridazine, tricyclic antidepressants, trifluoperazine, trimethoprim, vasopressin, venlafaxine, ziprasidone, zolmitriptan.

Rants and Screeds

Pearls

Treatment of choice

Use for

P. falciparum and P. vivax.

Don't use for

Class