Infectious Disease Compendium

Ganciclovir (Cytovene®)

(dosing from PDR)

Not available in US since 2012)

Dosing

CrCl Formula

CrCl > 70: 5 mg/kg q 12 IV; 1 gm po tid.

CrCl 69-50: 2.5 mg/kg q 12 h iv; 1.5 gm po qd.

CrCl 49-25: 2.5 mg/kg q 24 iv; 1 gm po qd.

CrCl 24 - 10: 1.25 mg/kg iv; 0.5 gm po qd.

CrCl < 10: 1.25 mg kg iv 3x wk; 0.5 g po 3x wk.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Cytopenias, anemia, neutropenia (common), thrombocytopenia, anorexia, fever, phlebitis.

Important drug interactions

Didanosine, imipenem, mycophenolate mofetil, mycophenolate sodium, mycophenolic acid, probenecid, tacrolimus, zidovudine.

Rants and Screeds

Pearls

Treatment of choice

Use for

CMV.

Don't use for

Class

Acyclic nucleoside.