Infectious Disease Compendium

Fosfomycin

Dosing

CrCl Formula

It comes in the ever so quaint sachet.

Women: years: 3 g PO once

Males: 3 g every 2-3 days for 3 doses

IV is 8-24 grams a day.

Important side effects

IV has a lot of sodium.

Important drug interactions

Rants and Screeds

Pearls

Can be synergistic with beta-lactams.

Effective against E. faecalis, E. coli, Citrobacter and Proteus. Pseudomonas may have more ability to be resistant, but less perhaps than other antibiotics.

May be useful with MDRO and XDR (PubMed).

Resistance is rare in the US but common in China.

Treatment of choice

Use for

UTI (PubMed) . Maybe prostatitis.

Don't use for

Pyelonephritis

Class

phosphonic acid derivative it inhibits bacterial cell wall synthesis