Infectious Disease Compendium

Fosamprenavir (Lexiva®)

Dosing

CrCl Formula For up-to-date information, go to http://hivinsite.ucsf.edu/tables.

CrCl > 80:

HIV infection: treatment-naive patients; fosamprenavir 1400 mg po bid, OR fosamprenavir 1400 mg plus ritonavir 200 mg po qd, OR fosamprenavir 700 mg plus ritonavir 100 mg po bid.

HIV infection: treatment-naive patients in combination with efavirenz; fosamprenavir 1400 mg plus ritonavir 300 mg po qd (100 mg additional ritonavir/day).

HIV infection: protease inhibitor-experienced patients; fosamprenavir 700 mg plus ritonavir 100 mg po bid.

HIV infection: protease inhibitor-experienced patients; once-daily fosamprenavir plus ritonavir is NOT recommended in this group of patients.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Diabetes mellitus (new onset, exacerbation), diarrhea, nausea, vomiting, fatigue, headache, rash, severe skin reactions including stevens-johnson syndrome (rare).

Important drug interactions

Alprazolam, amineptine, amiodarone, amitriptyline, amlodipine, amoxapine, atorvastatin, bepridil, carbamazepine, cisapride, clomipramine, clorazepate, cyclosporine, delavirdine, desipramine, desogestrel, dexamethasone, diazepam, dibenzepin, dihydroergotamine, diltiazem, dothiepin, doxepin, drospirenone, efavirenz, ergoloid mesylates, ergonovine, ergotamine, ethinyl estradiol, ethynodiol diacetate, etonogestrel, felodipine, fentanyl, flurazepam, fosphenytoin, imipramine, indinavir, isradipine, lidocaine, lofepramine, lovastatin, melitracen, mestranol, methylergonovine, midazolam, nelfinavir, nevirapine, nicardipine, nifedipine, nimodipine, nisoldipine, norelgestromin, norethindrone, norgestimate, norgestrel, nortriptyline, opipramol, phenobarbital, phenytoin, pimozide, protriptyline, quinidine, ranitidine, rifabutin, rifampin, rifapentine, saquinavir, sildenafil, simvastatin, sirolimus, st john's wort, tacrolimus, tadalafil, tianeptine, triazolam, trimipramine, vardenafil, verapamil, voriconazole, warfarin.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV.

Don't use for

Use for

Class

Reverse transcriptase inhibitor.