Infectious Disease Compendium

Flucytosine (Ancobon®)

Dosing

CrCl Formula

CrCl > 80: 37 mg/kg q 6-hours.

CrCl 80-50: 6h.

CrCl 50-10: 12-24h.

CrCl < 10: 15-25 mg/kg q24h.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Toxic megacolon and cytopenias.

Important drug interactions

Amphotericin B liposome, cytarabine, levomethadyl, zidovudine,

Rants and Screeds

Pearls

Keep blood levels between 20 and 100 micrograms per ml.

In 2016 it is $2000 a DAY, part of ongoing price gouging and profiteering.

Treatment of choice

Use for

Used synergistically with amphotericin B against Candida and cryptococcus.

Don't use for