Infectious Disease Compendium

Fidaxomicin

2012 Review

Dosing

200 mg po bid.

Important side effects

Even though not absorbed, it can still cause a hypersensitivity reaction (PubMed).

Rants and Screeds

Currently (Dec 2011) a course is around three thousand dollars. Really. $3,000. Can you say price gouge?

Pearls

Treatment of choice

Use for

C. difficile diarrhea. Equal cure rates to vancomycin, fewer relapses (PubMed). It is cidal and has a prolonged post antibiotic effect; the first is probably unimportant, the second probably not so much much.

Don't use for

Class

Macrocyclic antibiotic; inhibits the bacterial RNA polymerase,