Infectious Disease Compendium

Ethionamide (Trecator-SC®)

Dosing

CrCl Formula

CrCl > 80: The initial dosage is 250 mg bid (or as a single dose at bedtime), increased by 250 mg daily until 1 g/day in divided doses. Usually, 500 to 750 mg is the maximal tolerated dose.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

Aminosalicyclic acid, cycloserine, ethanbutol, isoniazid, pyrazinamide, rifampin; all increase toxicity.

Rants and Screeds

Pearls

Treatment of choice

Use for

A second line treatment for Tuberculosis and other Mycobacterium infections.

Don't use for