Infectious Disease Compendium

Erythromycin

Dosing

CrCl Formula

CrCl 80-50: 250- 500 mg po qid.

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Use the EES form, the least prone to side effects such as hepatitis and transient hearing loss. Can be puke central as it binds to the gi motility receptor, which is also why it is used in diabetic gastroparesis.

Important drug interactions

When gven to patients on calcium-channel blockers increased risk for hypotension or shock requiring hospitalization; not an issue with azithromycin.

Alfentanil, alfuzosin, alprazolam, anisindione, antipsychotics, arsenic trioxide, astemizole, atorvastatin, autumn crocus, bepridil, bexarotene, buspirone, carbamazepine, cerivastatin, chloral hydrate, chloroquine, cilostazol, cinacalcet, cisapride, clarithromycin, class i antiarrhythmic agents, class ia antiarrhythmic agents, class iii antiarrhythmic agents, clarithromycin, clozapine, colchicine, cotrimoxazole, cyclosporine, diazepam, dicumarol, digoxin, diltiazem, dofetilide, dolasetron, droperidol, eletriptan, enflurane, entacapone, ergot derivatives, ethinyl estradiol, etonogestrel, felodipine, fentanyl, fluconazole, fluoxetine, fluvastatin, foscarnet, gemifloxacin, grepafloxacin, halofantrine, halothane, imatinib, isoflurane, isradipine, itraconazole, ketoconazole, levomethadyl, levonorgestrel, lidoflazine, lovastatin, mefloquin, mesoridazine, mestranol, midazolam, moxifloxacin, norelgestromin, norethindrone, norgestrel, octreotide, pentamadine, phenothiazines, phenprocoumon, pimozide, pravastatin, probucol, quetiapine, sertraline, sibutramine, sildenafil, simvastatin, sirolimus, sparfloxacin, spiramycin, sulfamethoxazole, tacrolimus, tadalafil, telithromycin, terfenadine, theophylline, thioridazine, tolterodine, triazolam, tricyclic antidepressants, trimethoprim, trimetrexate, troleandomycin, valproic acid, vardenafil, vasopressin, venlafaxine, verapamil, voriconazole, warfarin, ziprasidone, zolmitriptan.

Rants and Screeds

Pearls

Treatment of choice

Use for

Amebiasis, Bacille Calmette-Guérin (bcg) infections, bacterial Endocarditis - prophylaxis, Bites, animal, blepharokeratitis, Bronchitis, bullous pemphigoid, Campylobacter jejuni infections, Cellulitis, Chancroid, Chlamydia trachomatis, Cholera, Conjunctivitis, Corynebacterium jeikeium infections, Diptheria, Eikenella corrodens infections, endocervical infections, Entamoeba histolytica, Flavobacterium infections, gastroparesis, genital Mycoplasm, Giardia lamblia, Haemophilus influenzae infections, impetigo, intraocular discitis, Legionella, Lyme Disease, Lymphogranuloma venereum, Moraxella catarrhalis infections, Mycobacterium infections, Mycoplasm pneumonia, neonatal conjunctivitis, neonatal pneumonia, nongonococcal Urethritis, Otitis media, Pertussis, Plasmodium falciparum, Pneumonia, premature rupture of membranes in pregnancy, preoperative bowel preparation, preterm labor, Prostatitis, Proctitis, respiratory infections, Rheumatic Fever prophylaxis, Syphilis, Ureaplasma urealyticum infections, Urethritis, Whipples disease.

Don't use for