Infectious Disease Compendium

Efavirenz (Sustiva®)

Dosing

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/.

CrCl > 80: 600 mg po qd.

There will be fewer side effects if you start slow: 200 mg first week, 400 mg the second then get to the 600 a day (PubMed).

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Rash and nightmares, neuropsychiatric, fat redistribution.

Important drug interactions

Alfuzosin, amprenavir, astemizole, atazanavir, carbamazepine, caspofungin, cisapride, clarithromycin, eletriptan, ergot derivatives, fosamprenavir, fosphenytoin, indinavir, lopinavir, methadone, midazolam, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, st john's wort, triazolam, voriconazole.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV.

Don't use for

Class

NNRTI: Non Nucleoside Reverse Transciptase Inhibitor