Pulled from the market in 2011 as repeat studies demonstated it is not better than placebo. 20 grand a course for nothing. A lesson on the importance of remembering that most of medical literature is wrong.
Dosing CrCl > 80: intravenously at a constant infusion rate of 24 microgram/kg/h for a total duration of infusion of 96 hours. No change for decrease in renal function. Absolute Contraindications: Active internal bleeding.
Recent (within 3 months) hemorrhagic stroke.
Recent (within 2 months) intracranial or intraspinal surgery, or severe head trauma.
Trauma with an increased risk of life-threatening bleeding.
Presence of an epidural catheter.
Intracranial neoplasm or mass lesion or evidence of cerebral herniation. Relative Contraindications: Concurrent therapeutic heparin.
Platelet count <30,000, even if the platelet count is increased after transfusions.
Prothrombin time-INR >3.0.
Recent (within 6 weeks) gastrointestinal bleeding.
Recent administration (within 3 days) of thrombolytic therapy.
Recent administration (within 7 days) of oral anticoagulants or glycoprotein IIb/IIIa inhibitors.
Recent administration (within 7 days) of aspirin >650 mg per day or other platelet inhibitors.
Recent (within 3 months) ischemic stroke (see CONTRAINDICATIONS).
Intracranial arteriovenous malformation or aneurysm.
Known bleeding diathesis.
Chronic severe hepatic disease.
Any other condition in which bleeding constitutes a significant hazard or would be particularly difficult to manage because of its location.
Important side effects Bleeding bleeding and more bleeding